Oil From the Sea

The Institute of Medicine recommendation to consume at least two servings of EPA /DHA cold water fish per week has created a business boom reminiscent of the decade old dot.com crazies.

As appreciation of the cardio, neuro and retina protective properties of the long-chain fish oil derived omega-3 fatty acids (EPA and DHA) has grown, so too have the dietary guidelines. An article in the September 2007 Journal of Cardiovascular Medicine recommended minimal intakes to either maintain the status quo (100-200 mg /day in most Western countries) or a minimum of 400-600 mg /day to lower the risk of cardiovascular or retina disease.

This science is music and money to the ears of the food fortification industry that is now targeting a vast array of packaged foods for EPA/DHA fortification. Gross overconsumption of EPA/DHA could well become a national health problem before the decade is over without government intervention in the food industry.

An article in the September Food Science and Technology Journal discusses the stability of 400 mg fish oil eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in cream-filled sandwich cookies (think Twinkie). These high glycemic cookies were packaged under vacuum or atmospheric conditions and stored for 28 days. They were not stale-they had no aftertaste and no loss of EPA and DHA during storage. What will the U.S. junk food industry try next?

So how does this new oil strike affect our wallets?

• The pharmaceutical industry is now selling concentrated fish oil, as prescription medicine, for five times the per milligram cost of OTC concentrated EPA /DHA from fish oil.

• Some companies are adding insignificant amounts of nutrients to their fish oil to capture disease-specific markets, such as eye care and charging excessive amounts per mg for EPA /DHA.
  

Too much of a good thing is definitely too much where fish oil is concerned.

Regular ingestion of reasonable amounts of Omega-3 EPA can successfully modulate the silent inflammatory process for many people. However, too much Omega-3 EPA can disrupt inflammatory process essential fatty acid (EFA) homeostasis, thereby preventing optimal inflammatory response when it's needed to spike a temp to kill off bacteria, start the clotting process if bleeding, or create swelling around a tissue injury.

Omega-3 DHA (directly metabolized from EPA) is the most abundant essential fatty acid in the brain and the retina. However, very excessive intake of DHA has been linked to increased mortality following cardiac events.

As a population, non fish eaters became DHA deficient due to cattle being taken off grass and fed grain before butchering, plus there is far less DHA in eggs in today's world due to factory farming. Unfortunately, the conversion of Omega-3 Flax Seed Oil to EPA is not dependable, therefore causing many Flax Seed Oil loving vegetarians to actually be EPA/DHA deficient.

The obvious question: What happens to future generations who will also need EPA/DHA in their diets if industry is allowed to deplete the seas of cold water fish to satisfy, yet another industry driven, perceived dependency on oil ?

Do You Ever Wonder?

Do you ever wonder what goes on between the scientists researching new ideas, or controversial concepts? I thought it might be of interest to readers to share an actual exchange between three of the scientists of a nutraceutical company (Biosyntrx) as they debate the understanding of a condition and the possible role of nutritional supplements in answer to a question frequently heard from patients.

One should not draw the conclusion from this exchange that any one of us has the final answer. But the exchange of ideas is challenging and exciting, and this is what makes it all worthwhile.

The participants in this exchange are Ellen Troyer, Executive Vice President and Chief Research Officer of Biosyntrx, Dr. Jeffrey Anshel, a nationally known optometric educator and member of Biosyntrx Scientific Advisory Board, and Spencer Thornton, M.D., president of Biosyntrx.

The background of this particular exchange is a question frequently asked of eye specialists that was directed to Dr. Anshel recently. “What causes the floaters that interfere with vision?”
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To: Dr. Jeffrey Anshel
Date: Friday, 19 Oct 2007 06:25:15 -0700
Subject: RE: Nutritional Supplements
Dear Dr. Anshel:
Many patients have been asking me if nutritional supplements will help with vitreous floaters. Any news about this?
Thanks!
LL, OD
-------------------------
From: Dr. Jeffrey Anshel
Sent: Saturday, October 20, 2007 12:47 AM
To: Ellen Troyer
Subject: Fwd: Re: nutritional supplements

I was going to tell this doctor ”No”, but just thought I'd run it past you
first (can't think of anything new at the moment). Maybe you have some thoughts about it. JA
--------------------------
From: Ellen Troyer
Date: Sat, 20 Oct 2007 08:35:05 -0600
To: "'Dr. Jeffrey Anshel'"
Cc:
Subject: RE: Re: nutritional supplements

The question is, are vitreous floaters cellular debris? When I had the YAG done to open holes in the film that had grown over the back of my IOLs, I had almost no floaters, which is apparently most always a complaint for a few days post YAG treatment. Kevin Waltz and I wondered if I had almost none because I was taking so many scavenging antioxidants. This is not proven science, so be careful using it as anything other than a possibility. Spencer will surely have some thoughts on this subject. ET
------------------------
From: "Dr. Jeffrey Anshel"
Date: Sat, 20 Oct 2007 09:26:15 -0700
To: Ellen Troyer
Cc:
Subject: RE: Re: nutritional supplements

Technically, yes it is cellular debris, but it's embryonic cellular debris, so most of it is there from birth! I don't see how it relates to anything related to YAG capsulectomy.
JA
--------------------------
From: Spencer Thornton
Date: Sat, 20 Oct 2007 23:30:30 -0500
To: Jeffrey Anshel , Ellen Troyer
Subject: Re: Thoughts on floaters

I have to disagree with the statement that “technically, vitreous floaters are embryonic cellular debris”. There is one type of floater that is embryonic in origin, and that is the small protein clumps that are remnants of embryonic structures. These are referred to as “congenital” floaters. These may be seen at any age, and are more common in myopic young people.

The most common cause of floaters in adults is degeneration of the vitreous, which consists of 99% water and 1% solid elements. The solid portion consists of a network of collagen and hyaluronic acid, with the latter retaining water molecules. Other components include salts, sugars, and phagocytes. The phagocytic cells in the vitreous serve to remove unwanted debris.

Though vitreous is 99% water, it has a gel like consistency because of its 1% collagen and hyaluronic acid content. Degeneration of the collagen network causes the hyaluronic acid to release its bound water, thereby liquefying the gel. The collagen then breaks down into fibrils, which ultimately are the floaters that people see. This is the “acquired type”, more commonly seen in older patients, and may vary in size, shape and consistency, appearing as spots, threads or cobwebs.

The collagen fibers of the vitreous are held apart by electrical charges. With aging and free radical accumulation, these charges tend to weaken, and the fibers tend to clump together. Also, the gel may liquefy, leading cells and other organic clusters to float freely within the vitreous humour. Floaters are generally harmless, but sudden onset of recurring floaters may signify a posterior vitreous detachment (PVD) or other diseases of the eye. Floaters may also appear in macular degeneration, cystoid macular edema, and after surgery that disturbs the vitreous.

Normally, there is no treatment indicated. Vitrectomy has been used in treating more severe cases; however, the procedure is typically not warranted in those with lesser symptoms due to the potential for complications. Another treatment is laser vitreolysis. In this procedure a YAG Laser is focused onto the floater and in a quick burst vaporizes the structure. There is no consensus as to how completely effective this is. Because of the degenerative nature of acquired vitreous floaters it would seem reasonable to believe that antioxidant supplements may help reduce or neutralize free radicals present. ST

---------------------------
From: "Dr. Jeffrey Anshel"
Date: Sat, 20 Oct 2007 22:22:25 -0700
To: Spencer Thornton , Ellen Troyer
Subject: Re: Thoughts on floaters

Thanks Spence! I agree with most of what you say but my impression of "acquired" floaters in the HEALTHY eye (important point) is that they are just more visible congenital floaters. The way I explain it to patients is that their existing floaters are suspended in a more substantial gel-like vitreous which softens and liquifies with age. The SAME floaters now become more visible due to their movement.

We agree that most surgical interventions tend to worsen the problem. I've looked at the YAG "treatment" for them and have seen mixed results- some better, most worse (seems that the laser "explodes" the floater to create more little ones).

We can discuss the process of vitreous degeneration and the role of antioxidants- any studies out there?? Would love to see that because this is such a common complaint (from this author as well!!!! ;-)). I'm sure the role of antioxidants has been just scratched at the surface so if we are on to something here, we'll all be happy!!!
JA
-------------------------
From: Spencer Thornton
Date: Sun, 21 Oct 2007 08:15:18 -0500
To: Jeffrey Anshel Ellen Troyer
Subject: Re: Thoughts on floaters
Jeff, Delighted to see your response.
Studies I did years ago on the micro-anatomy of the vitreous, with Jan Worst of Gronegran, Netherlands, showed that floaters in the healthy eye were not just more visible congenital floaters – they were developmental elements from the depolymerization of the hyaluronic acid and syneresis, leading to cells and other organic clusters floating free in the vitreous humor. This occurs in the healthy eye, and more prominently in the unhealthy eye.

On the role of antioxidants, I think Ellen is on to something. It’s hard to pin down some of my colleagues because they want to throw in all sorts of secondary modifying factors.

I have used YAG laser on anterior vitreous floaters with some success, but I think you are right about the creation of more “little” floaters when ablating larger (and more posterior) floaters. ST
-----------------------
From: "Dr. Jeffrey Anshel"
Date: Mon, 22 Oct 2007 08:23:42 -0700
To: Spencer Thornton Ellen Troyer
Subject: Re: Vitreous Floaters
Vitreous floaters come from several sources, including the chemical changes in clear substances like hyaluronic acid (as clear egg albumen can be changed into hard, non-transparent egg white). These chemical changes may be due to UV or infra-red light, or other stress factors that produce free radicals in the vitreous. The bottom line is that inasmuch as we know that antioxidants neutralize free radicals, formulations of broad spectrum multiples, with vitamins, antioxidants, and essential trace minerals may have a beneficial effect on free radicals in the vitreous, helping to reduce the incidence and severity of degenerative floaters.

People ask me why there are so few scientific studies on the genesis of floaters and the effect of nutraceuticals, and I point out to them that scientific studies cost a great deal of money and financial grants are generally made for development and evaluation of pharmaceuticals, not nutraceuticals. Compelling evidence is there however, and we are gradually learning that formulations like Macula Complete do have a free radical quenching effect, potentially benefiting the vitreous as well as the retina.

Jeff Anshel
-------------------

What will we learn from this debate? The research is ongoing. Stay tuned.

Higher Doses of Vitamin D Safe

A question from a customer regarding the safety of 1,200 IUs of Vitamin D in Macula Complete prompted this post.

A study on vitamin D3 and multiple sclerosis resulted in data supporting the use of much higher doses of vitamin D3 for clinical research, and provided evidence that vitamin D3 intake beyond the current upper limit of 2,000 IU per day is safe by a large margin.

The current RDA is only 400 IUs per day. Based on a large number of new peer-reviewed studies suggesting that number to be too low, the RDA is expected to triple in the coming year.

The study, published in the September issue of the American Journal of Clinical Nutrition, included 12 patients in an active phase of multiple sclerosis (MS) who were given 1,200 milligrams elemental calcium per day along with progressively increasing doses of vitamin D3—from 700 (2,800 IUs) to 7,000 micrograms (28,000 IUs) per week—to determine the
"tolerability" of higher doses of vitamin D that may be required for therapeutic efficacy therapy. This study specifically assessed how well the body handles calcium levels relative to vitamin D concentrations in the blood.

At the beginning of the 28-week study, mean serum concentrations of 25(OH)D were 78 ± 35 nmol/L, rising to 386 ± 157 nmol/L (P < 0.001). Mean values of serum calcium concentrations and the urinary ratio of calcium to creatinine—both biomarkers of which high levels are associated with problems processing calcium in the body—did not increase or exceed reference values for any participant. Additional related biomarkers including liver enzymes, serum creatinine, electrolytes, and serum protein levels did not change. Disease progression and activity were not affected, but there was a mean decrease in the number of MS-related lesions per patient.

Participants' serum vitamin D concentrations reached twice the top of the normal range without resulting in hypercalcemia or hypercalciuria—detrimental conditions linked to problems with the body's processing of excess calcium.

Clean Freak Mothers = Asthma

A recently published University of Alberta study found that children reared on a farm have less than half the risk of developing asthma as children who were reared by urban clean freak mothers.

Farm children ages 1 to 5 showed a stronger protective effect against asthma than those aged 6 to 11 years, probably due to earlier exposure to the farm environment.

Exposure to "endotoxins" from animal viruses and manure and avoidance of urban environment pollution early in life may very well reduce the risk for development of asthma.

European researchers also say that exposure to household cleaning sprays and air fresheners as little as once a week increases the risk of developing asthma.

Another study published in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine suggests that the relative risk rates of developing childhood or adult asthma in relation to exposure to cleaning products could account for as much as 15 percent, or one in seven of asthma cases.

This report also suggests that children with allergic sensitizations in economically developed countries are far more likely to develop asthma than similarly sensitized children in poorer countries.

The researchers speculated that some factors that protect children with allergic sensitization from developing asthma are less present in affluent settings, which might not provide the commensal bacteria necessary for tolerance and immune function development.

So much for what my former husband's maiden Aunt Lillian always said about the importance of maintaining an absolutely spotless house for my children's health!

Homocysteine Bad For Eyes

Science Daily reported on a study today that suggests homocysteine, an amino acid linked to heart attack, stroke and dementia, may also be a player in retinal damage and vision loss. Although the writer's explaination of methionine metabolism is way too simplistic, we will present the material just as they did in Science Daily.

....The study leader, Dr. Sylvis Smith of the Medical College of Georgia, explained that homocysteine levels rise when folic acid levels drop, a problem for many whose diets are poor in folate-rich fruits, tomatoes, vegetables and grains. Smith exposed layers of retina to high levels of homocysteine and found the retina "terribly disrupted."

"Folate and vitamin B12 convert homocysteine to methionine, an amino acid essential to protein synthesis. Without the conversion, rising homocysteine levels interfere with the folding and structure of collagen, a component of bone, tissue and the basement membrane of blood vessel walls," Smith said.

"At any point in your life, too much homocysteine can be problematic, whether you are talking about pregnant women, cardiovascular disease or dementia," Smith says in a statement. "If homocysteine is not converted into methionine or cysteine -- by vitamin B6 -- to aid protein synthesis, it can do something bad."

Science = Nobel Peace Prize

The 2007 Nobel Peace Prize was awarded jointly to the approximately 1000 world wide university scientists who contributed research to the Intergovernmental Panel on Climate Change (IPCC) for "their efforts to build up and disseminate greater knowledge about man-made climate change, and to lay the foundations for the measures that are needed to counteract such change."

This award reflects a global science consensus that man-made climate change is a crisis that can't be ignored.

The prize was also jointly awarded to former Vice President, Al Gore, for his 1992 book " Earth in the Balance: Ecology and the Human Spirit," and his 2006 Oscar winning documentary "An Inconvenient Truth." Al Gore gifted his entire $750,000 Nobel Prize money, as well as monies from his documentary to the Palo Alto, CA nonprofit organization, Alliance for Climate Protection http://www.climateprotect.org/

In spite of global warming concerns recently expressed by the White House, some politicians and radio talk show entertainers are using this selection as a chance to discredit the prestigious Nobel Peace Prize; reminiscent of the way the prize was discredited when Dr. Martin Luther King became the recipient in 1965.

With that said: Biosyntrx is in the process of making the few changes necessary to become a certified Green Business that will best work for our our customers, our planet and our business.

Avastin & Lucentis

Genentech is notifying ophthalmologists of a change to the distribution of Avastin (a cancer drug also being used to inhibit AMD associated retinal bleeds). Avastin sells for about $50 per dose vs. Lucentis, the new Ocular-specific version of Avastin being used in new AMD clinical studies, which we're told will cost the patient somewhere in the range of $2,000 per dose.

Beginning November 30th, the Lucentis compound must be ordered directly from Genentech, rather than purchased from a compounding pharmacy.

Both versions of this drug have been linked to increased risk of stroke.

The FDA and Genentech claim to be concerned about sterilization issues involved when compounding pharmacists divide Avastin into tiny portions for ocular use.