A study published in the June 2007 Neuroscience Letter suggests a higher consumption of the long-chain omega-3 fatty acids, EPA/DHA found in fish and fish oil to be associated with greater gray matter that supports emotion arousal and regulation.
Depression has been reported to be associated with increased cytokine production, such as the pro-inflammatory marker, Interleukin-6 (IL-6). A study published in the November 2002 Prostaglandins Leukot Essent Fatty Acids Journal suggested an inhibiting effect of DHA on cytokine synthesis, which suggests to us that some emotional arousal and clinical depression might be linked to chronic silent inflammation.
This study found that by increasing the amount of dietary EPA/DHA (DHA measured in adipose tissue) the levels of both IL-6 and depression decreased.
This might not be great news to the pharmaceutical industry and to those doctors who hand out scripts for antidepressents like candy to get, mostly middle-age women, out of their offices. Depression could be another symptom of the silent inflammation we now link to so many degenerative disease processes.
However, it's almost impossible to compete with pharmacutical advertising on network TV. So the best we can hope for is that mainstream medicine will acknowledge the large number of published studies strongly suggesting that patients who add a daily dose of concentrated fish oil to their regular antidepressant treatment experience fewer side effects; including flat affect (the dead giveaway), sleeping problems, and decreased sexual desire.