A mouse study published in the December 2007 issue of the Journal of Nutrition suggests a B vitamin deficiency increases the risk of DNA damage and colorectal cancers.
A number of studies have linked folate deficiency to colon cancer. However, many biochemical functions of folate are dependent on adequate availability of other B vitamins, including B6, B12 and riboflavin.
The researchers in the new Journal of Nutrition study suggested that a mild depletion of folate alone did not affect DNA, but a mild depletion of all four B vitamins significantly increased the DNA damage on the tumor suppressor gene, adenomatosis polyposis coli gene (Apc).
We can't stress enough the importance of supplementing with a full-spectrum multiple that includes all of the B complex vitamins.