Thursday, August 16, 2007

Grapefruit Intake & Breast Cancer?

This may come as a surprise to lovers of grapefruit.

An epidemiological study published in the July 2007 British Journal of Cancer suggets there could be a correlation between grapefruit consumption and breast cancer in menopausal and post-menopausal women.

The biological plausible mechanism of action for the observed effect is that grapefruit is a well known cytochrome CYP34A inhibitor (membrane-bound hemoprotein enzyme). As a result, regular consumption of grapefruit can increase circulating concentrations of estrogens, which are otherwise metabolized by these enzymes.

Higher systemic levels of estrogens are associated with a increased risk of breast cancer in older women.

The study conclusion suggests the information in this study might be sufficient for menopausal and post-menopausal women to limit their grapefruit consumption.

FYI: The Texas red grapefruit was designated the offiicial state fruit in 1993. Given the large number of people that could be affected by the study above; they may want to rethink this decision.


Dr. Lucia said...

There goes my favorite breakfast fruit.

Larry said...

Grapefruit interferes with the metabolism of number of prescription drugs, so it's a good idea to question your doctor about this possibility whenever he/she writes you a script for a drug.

"The Girls" said...

Thank you from all the menopausal and postmenopausal women who follow your dilligent research.